Attenuation of iNOS and COX2 by blueberry polyphenols is mediated through the suppression of NF-κB activation

Autor: Francis C. Lau, James A. Joseph, Jane E. McDonald, Wilhelmina Kalt
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: Journal of Functional Foods, Vol 1, Iss 3, Pp 274-283 (2009)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2009.05.001
Popis: Treatment of BV2 microglial cells with blueberry extracts has been shown to be effective in reducing lipopolysaccharide (LPS)-induced proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), inducible NO synthase (iNOS), and cyclooxygenase 2 (COX2). The current study explored the possibility that the down-regulation of iNOS and COX2 by blueberry extracts was mediated through NF-κB signaling pathway. A column-purified fraction of polyphenol-enriched blueberry extract (PC18) was used to treat LPS-activated BV2 cells. The results thus far showed that blueberry polyphenols significantly suppressed iNOS and COX2 promoter activities. In addition, blueberry polyphenols inhibited NF-κB nuclear translocation in LPS-activated BV2 cells. These findings suggested that the beneficial effects of blueberries may involve direct modulation of oxidative stress and/or inflammatory signaling cascades.
Databáze: Directory of Open Access Journals
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