rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum woman

Autor: Jojo Yorke, Krupa Solanki, Vaishnavi Theegala, Alok Sinha, Don Asberry, Adel El Abbassi
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: European Journal of Case Reports in Internal Medicine (2023)
Druh dokumentu: article
ISSN: 2284-2594
DOI: 10.12890/2023_003626
Popis: Introduction: Inflammatory myofibroblastic tumours are rare neoplasms which most commonly affect children and young adults. With an intermediate malignant potential, they are typically detected in the abdomen, lung, mediastinum, head and neck, gastrointestinal tract, and genitourinary tract. Case description: We describe the case of a 33-year-old postpartum woman incidentally diagnosed with a pulmonary inflammatory myofibroblastic tumour following complaints of poorly controlled hypertension a week after caesarean section. She was ALK-negative and received an ALK inhibitor with complete resolution of the lesion. A ROS1–TFG fusion confirmed the diagnosis of an inflammatory myofibroblastic tumour after CT-guided fine needle aspiration. Discussion: This case highlights an uncommon presentation posing a diagnostic and therapeutic challenge and the potential treatment option of crizotinib.
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