Effects of Omegaven®, EPA, DHA and oxaliplatin on oesophageal adenocarcinoma cell lines growth, cytokine and cell signal biomarkers expression

Autor:	Amar M. Eltweri, Lynne M. Howells, Anne L. Thomas, Ashley R. Dennison, David J. Bowrey
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Nutritional diseases. Deficiency diseases RC620-627
Zdroj:	Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-9 (2018)
Druh dokumentu:	article
ISSN:	1476-511X
DOI:	10.1186/s12944-018-0664-1
Popis:	Abstract Background There is limited evidence assessing the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oesophageal adenocarcinoma, both in vitro and in vivo. We evaluated the effects of the omega-3 PUFA and oxaliplatin on OE33 and OE19 cells. Method The two oesophageal cells were treated with Omegaven® (fish oil emulsion), EPA, DHA and oxaliplatin and incubated for up to 144 h. Results The following inhibitory effects were observed on OE33 cells: EPA reduced cell growth by 39% (p = 0.001), DHA by 59% (p
Databáze:	Directory of Open Access Journals
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