Effects of hydromorphone-based patient-controlled intravenous analgesia on postoperative hypoxaemia: a randomised controlled non-inferiority clinical trial
| Autor: | Xuan Yang, Ziyu Zheng, Yumei Ma, Zhuomin Deng, Xiangying Feng, Jialin Luo, Yang Meng, Jingjing Lin, Xiaoxiao Mu, Huang Nie, Hailong Dong, Nong Yan, Jiejuan Du |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | BMJ Open, Vol 14, Iss 7 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2024-0848 2044-6055 |
| DOI: | 10.1136/bmjopen-2024-084827 |
| Popis: | Objective This study aimed to compare the effects of patient-controlled intravenous analgesia (PCIA) with and without low-basal infusion on postoperative hypoxaemia.Design A randomised parallel-group non-inferiority trial.Setting The trial was conducted at a grade-A tertiary hospital from December 2021 to August 2022.Participants 160 adults undergoing gastrointestinal tumour surgery and receiving postoperative PCIA.Interventions Participants randomly received a low-basal (0.1 mg/hour of hydromorphone) or no-basal infusion PCIA for postoperative 48 hours.Primary and secondary outcome measures Primary outcome was area under curve (AUC) per hour for hypoxaemia, defined as pulse oxygen saturation (SpO2) |
| Databáze: | Directory of Open Access Journals |
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