| Autor: |
Hassan El-Abid, Cristina Amaral, Sara C. Cunha, Tiago V. Augusto, José O. Fernandes, Georgina Correia-da-Silva, Natércia Teixeira, Mohieddine Moumni |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 59, Iss , Pp 261-271 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2019.05.042 |
| Popis: |
Fruits from Juniperus oxycedrus L. (Cupressaceae) are generally used in gastronomy and in folk medicine to treat cancer. In this study, the anti-cancer efficacy of essential oils (EOs) of fruits and leaves from Moroccan J. oxycedrus L., was investigated in ER+ breast cancer cells. Both EOs presented anti-proliferative effects but, curiously, only fruits EOs impaired cancer cell growth and induced apoptosis. To characterize the chemical composition of these EOs, a suitable HS-SPME/GC–MS method was developed. Among the SPME fibers used, the PDMS and PA were the most effective for characterization of volatile compounds. Moreover, these EOs are rich in α-pinene and β-myrcene, which also presented anti-cancer properties. For the first time, the anti-cancer properties of EOs and of new potential bioactive molecules of J. oxycedrus L. in ER+ breast cancer cells were highlighted, suggesting their potential adjuvant therapeutic role in breast cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect