| Autor: |
Yuji Moriwaki, Chihiro Okuda, Asako Yamamoto, Tsuneyoshi Ka, Zenta Tsutsumi, Sumio Takahashi, Tetsuya Yamamoto, Kentaro Kitadate, Koji Wakame |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 3, Iss 1, Pp 13-16 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2010.11.002 |
| Popis: |
Epidemiological observations and laboratory studies have suggested that polyphenols possess anti-inflammatory, anti-microbial, anti-carcinogenic, and antioxidant properties. However, studies assessing the effects of polyphenols on uric acid metabolism in vivo are scarce. Herein, we investigated whether a phenolic substance, Oligonol®, has effects on uric acid metabolism. In six healthy male volunteers, Oligonol® significantly decreased 1-h uric acid excretion and fractional uric acid clearance, which was accompanied by a decreased serum concentration of uric acid. In addition, an in vitro experiment showed that Oligonol® inhibited buttermilk xanthine oxidase activity in a dose-dependent manner. Together, these results suggest that Oligonol® lowers serum uric acid through inhibition of xanthine oxidase, and may be effective for prevention and treatment of hyperuricemia and/or gout. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect