| Autor: |
Rohit Chavan, Nadia Preitner, Takashi Okabe, Laureen Mansencal Strittmatter, Cheng Xu, Jürgen A. Ripperger, Nelly Pitteloud, Urs Albrecht |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Biology Open, Vol 6, Iss 1, Pp 1-7 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2046-6390 |
| DOI: |
10.1242/bio.021519 |
| Popis: |
The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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