Comparison of the efficacy and safety of insulin degludec/aspart (twice‐daily injections), insulin glargine 300 U/mL, and insulin glulisine (basal–bolus therapy)

Autor: Yuji Kawaguchi, Jun Sawa, Chie Hamai, Yuri Nishimura, Yasuro Kumeda
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 10, Iss 6, Pp 1527-1536 (2019)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.13038
Popis: Abstract Aims/Introduction We compared the efficacy and safety of insulin degludec/aspart (IDegAsp) twice‐daily injections with insulin glargine 300 U/mL and insulin glulisine basal–bolus therapy (Gla300/Glu) using insulin glargine 300 U/mL (Gla300) and insulin glulisine (Glu). Materials and Methods A total of 20 patients with type 2 diabetes mellitus were treated with IDegAsp twice‐daily injections; achievement of target preprandial glucose concentration of 100–130 mg/dL at breakfast and supper was determined using a wearable flash glucose monitoring system. Patients were later switched to Gla300/Glu basal–bolus therapy before breakfast and before supper. Data were collected on days 2–4 and days 12–14 for each treatment period. The study's primary efficacy end‐point was the mean percentage of time with a target glucose range of 70–180 mg/dL, and safety end‐points were the mean percentage of time with hypoglycemia having glucose levels
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje