| Autor: |
Emma L. Twait, Jen-Hao Wu, Maria Kamarioti, Maartje Basten, Wiesje M. van der Flier, Lotte Gerritsen, Mirjam I. Geerlings |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2158-3188 |
| DOI: |
10.1038/s41398-024-02739-9 |
| Popis: |
Abstract Several lines of evidence have indicated that depression might be a prodromal symptom of Alzheimer’s disease (AD). This systematic review and meta-analysis investigated the cross-sectional association between amyloid-beta, one of the key pathologies defining AD, and depression or depressive symptoms in older adults without dementia. A systematic search in PubMed yielded 689 peer-reviewed articles. After full-text screening, nine CSF studies, 11 PET studies, and five plasma studies were included. No association between amyloid-beta and depression or depressive symptoms were found using cerebrospinal fluid (CSF) (0.15; 95% CI: −0.08; 0.37), positron emission topography (PET) (Cohen’s d: 0.09; 95% CI: −0.05; 0.24), or plasma (−0.01; 95% CI: −0.23; 0.22). However, subgroup analyses revealed an association in plasma studies of individuals with cognitive impairment. A trend of an association was found in the studies using CSF and PET. This systematic review and meta-analysis suggested that depressive symptoms may be part of the prodromal stage of dementia. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink