| Autor: |
Persico Marco Giovanni, Buroni Federica Eleonora, Pasi Francesca, Lodola Lorenzo, Aprile Carlo, Nano Rosanna, Hodolic Marina |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Radiology and Oncology, Vol 50, Iss 2, Pp 153-158 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1581-3207 |
| DOI: |
10.1515/raon-2016-0022 |
| Popis: |
Despite complex treatment of surgery, radiotherapy and chemotherapy, high grade gliomas often recur. Differentiation between post-treatment changes and recurrence is difficult. 18F-methyl-choline (18F-FCH) is frequently used in staging and detection of recurrent prostate cancer disease as well as some brain tumours; however accumulation in inflammatory tissue limits its specificity. The 18F-ethyl-tyrosine (18F-FET) shows a specific uptake in malignant cells, resulting from increased expression of amino acid transporters or diffusing through the disrupted blood-brain barrier. 18F-FET exhibits lower uptake in machrophages and other inflammatory cells. Aim of this study was to evaluate 18F-FCH and 18F-FET uptake by human glioblastoma T98G cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
