Investigating the Therapeutic Potential of Clove Extract in Mitigating Testicular Injury Associated With Testicular Hypoxia in Male Rats

Autor: Sara Parsania, Somaye Salehpoor, Maryam Sadrr Ameli, Morteza Abdi, Majid Shokoohi, Alireza Rahimi Mamaghani, Leila Majdi
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Crescent Journal of Medical and Biological Sciences, Vol 11, Iss 3, Pp 128-134 (2024)
Druh dokumentu: article
ISSN: 2148-9696
DOI: 10.34172/cjmb.2024.3733
Popis: Objectives: This study aims to comprehensively assess the therapeutic potential of clove extract in mitigating testicular damage and preserving male reproductive function under hypoxic conditions in male rats. Materials and Methods: We randomly divided 24 male rats into three groups: a hypoxia group that just received normal saline, a hypoxia + clove extract (4 mg/kg) group, and a sham operation group without treatment. After eight weeks, the serum level of oxidative stress parameters was examined, and the testicle histopathological examination, such as seminiferous tubule diameters and epithelium thickness, was assessed. Results: The serum malondialdehyde (MDA) concentration was significantly enhanced in the hypoxic group, and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) declined (P
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