Screening of prognostic factors and survival analysis based on histological type for perimenopausal endometrial carcinoma treated with hysterectomy

Autor: Luyao Kang, Gaili Ji, Duan Liu, Yaping Wang, Jie Meng, Hongyu Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Discover Oncology, Vol 15, Iss 1, Pp 1-13 (2024)
Druh dokumentu: article
ISSN: 2730-6011
DOI: 10.1007/s12672-024-01403-4
Popis: Abstract Purpose This study aimed to explore the prognostic factors and survival patterns based on the histological type for the perimenopausal endometrial carcinoma (PIPEC) patients treated with hysterectomy. Methods The PIPEC patients were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Methods of random survival forest (RSF) and Cox regression were used to identify the possible prognostic factors of PIPEC patients. Then overall survival (OS) and cancer-specific survival (CSS) of PIPEC data were analyzed by histological types with regional lymph nodes status and SEER-stage to investigate the survival patterns of the PIPEC patients. Results A total of 14,178 PIPEC patients were included in the study. We found tumor size, grade, histology, SEER-stage, AJCC-stage, AJCC-T stage, metastasis to distant organs and regional lymph nodes status had a significant survival outcome for PIPEC both for OS and CSS (all p
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