The correlation between uremic pruritus and blood lead levels in prevalent hemodialysis patients and its relation to the severity of pruritus using visual analog score

Autor: Sahar Mahmoud Shawky, Reeham Abdel Aziz Abdel Hamid, Lina Essam Khedr
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: The Egyptian Journal of Internal Medicine, Vol 33, Iss 1, Pp 1-7 (2021)
Druh dokumentu: article
ISSN: 1110-7782
2090-9098
DOI: 10.1186/s43162-021-00045-0
Popis: Abstract Background Pruritus is a common and often distressing symptom in patients with chronic kidney disease. Though the pathogenesis of uremic pruritus remains poorly understood, systemic inflammation has presented itself as one of the possible explanations. High blood lead levels (BLLs) have been noted to be associated with inflammation and poor nutritional status in hemodialysis patients. Our aim is to study the relation between blood lead levels and uremic pruritus. This is a cross-sectional study that enrolled 50 patients; all were on regular hemodialysis 3 times per week for at least 6 months. Patients were divided into 2 groups, group 1 (n =10) with no pruritus and group 2 (n=40) with varying degrees of pruritus. Group 2 was further divided according to intensity of pruritus by visual analog score (VAS) into mild (n=10), moderate (n=20), and severe pruritus (n=10). Results There was a significant difference in serum lead levels and ferritin levels between groups 1 and 2 (p value
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