Metastatic glioblastoma to the lungs: a case report and literature review

Autor:	Carlen A Yuen, Melike Pekmezci, Silin Bao, Xiao-Tang Kong
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	extra-neural glioblastoma gliosarcoma lenvatinib metastatic glioblastoma vascular endothelial growth factor inhibitor VEGF Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	CNS Oncology, Vol 13, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	20450907 2045-0915 2045-0907
DOI:	10.1080/20450907.2024.2351789
Popis:	Glioblastoma is the most common malignant primary brain tumor. Despite its infiltrative nature, extra-cranial glioblastoma metastases are rare. We present a case of a 63-year-old woman with metastatic glioblastoma in the lungs. Sarcomatous histology, a reported risk factor for disseminated disease, was found. Genomic alterations of TP53 mutation, TERT mutation, PTEN mutation, and +7/-10 were also uncovered. Early evidence suggests these molecular aberrations are common in metastatic glioblastoma. Treatment with third-line lenvatinib resulted in a mixed response. This case contributes to the growing body of evidence for the role of genomic alterations in predictive risk in metastatic glioblastoma. There remains an unmet need for treatment of metastatic glioblastoma.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/925db50d702243e1a7e495190f96a876 Zobrazit plný text záznamu View record in DOAJ