| Autor: |
Giulia Bonfante, Emanuela Fantinel, Cristina Masini, Franco Bergamaschi, Salvatore Micali, Bernardo Rocco |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Urology Case Reports, Vol 34, Iss , Pp 101444- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2214-4420 |
| DOI: |
10.1016/j.eucr.2020.101444 |
| Popis: |
Most common sites of metastasis of urothelial carcinoma (UC) are lungs, liver, lymph nodes and bone. Pembrolizumab, a humanized monoclonal antibody directed against programmed cell death protein-1 (PD-1), represents an effective second-line therapy for advanced UC. Radiotherapy has been shown to induce a mechanism of immunogenic cell death (ICD) resulting in immune memory and advantageous systemic effects. We present the first case of breast metastasis (BM) from a UC described in literature who had an exceptional response to second-line therapy with pembrolizumab in association with radiotherapy, showing the efficacy of combining immunotherapy and radiotherapy even in patients with atypical metastatic sites. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
