Sensitisation to molecular components of mites in atopic dermatitis patients

Autor: J. Čelakovská, E. Čermákova, R. Vaňková, P. Boudkova, C. Andrýs, J. Krejsek
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Food and Agricultural Immunology, Vol 33, Iss 1, Pp 588-603 (2022)
Druh dokumentu: article
ISSN: 09540105
1465-3443
0954-0105
92434436
DOI: 10.1080/09540105.2022.2100323
Popis: Background and aim: To analyse the sensitisation profile to molecular components of mites allergens with the use of ALEX2 Allergy Explorer test in Atopic dermatitis (AD) patients. Method: The complete dermatological and allergological examination including the examination of the sensitisation to molecular components with ALEX2 Allergy Explorer testing was performed. For the statistical analysis, we used Fisher's Exact. Results and conclusion: The sensitisation to mites increases with AD severity. The central role in atopic march may play the molecular component Der f 2 and Der p 23. The results of our study confirm the important role of Der p 5 and Der p 7 in subgroup of patients suffering from bronchial asthma. The specific immunotherapy should focus on the components of NPC2 family and Der p 23 in AD patients. Our results may be helpful in planning hyposensitisation, treatment and immunotherapy.
Databáze: Directory of Open Access Journals
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