| Autor: |
Andrew W Subudhi, Nicolas Bourdillon, Jenna Bucher, Christopher Davis, Jonathan E Elliott, Morgan Eutermoster, Oghenero Evero, Jui-Lin Fan, Sonja Jameson-Van Houten, Colleen G Julian, Jonathan Kark, Sherri Kark, Bengt Kayser, Julia P Kern, See Eun Kim, Corinna Lathan, Steven S Laurie, Andrew T Lovering, Ryan Paterson, David M Polaner, Benjamin J Ryan, James L Spira, Jack W Tsao, Nadine B Wachsmuth, Robert C Roach |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 9, Iss 3, p e92191 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0092191 |
| Popis: |
An understanding of human responses to hypoxia is important for the health of millions of people worldwide who visit, live, or work in the hypoxic environment encountered at high altitudes. In spite of dozens of studies over the last 100 years, the basic mechanisms controlling acclimatization to hypoxia remain largely unknown. The AltitudeOmics project aimed to bridge this gap. Our goals were 1) to describe a phenotype for successful acclimatization and assess its retention and 2) use these findings as a foundation for companion mechanistic studies. Our approach was to characterize acclimatization by measuring changes in arterial oxygenation and hemoglobin concentration [Hb], acute mountain sickness (AMS), cognitive function, and exercise performance in 21 subjects as they acclimatized to 5260 m over 16 days. We then focused on the retention of acclimatization by having subjects reascend to 5260 m after either 7 (n = 14) or 21 (n = 7) days at 1525 m. At 16 days at 5260 m we observed: 1) increases in arterial oxygenation and [Hb] (compared to acute hypoxia: PaO2 rose 9±4 mmHg to 45±4 while PaCO2 dropped a further 6±3 mmHg to 21±3, and [Hb] rose 1.8±0.7 g/dL to 16±2 g/dL; 2) no AMS; 3) improved cognitive function; and 4) improved exercise performance by 8±8% (all changes p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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