| Autor: |
Meng-Meng Jie, Xing Chang, Shuo Zeng, Cheng Liu, Guo-Bin Liao, Ya-Ran Wu, Chun-Hua Liu, Chang-Jiang Hu, Shi-Ming Yang, Xin-Zhe Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-15 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1478-811X |
| DOI: |
10.1186/s12964-019-0372-0 |
| Popis: |
Abstract Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer cell stemness maintaining, cell proliferation, apoptosis inhibition, senescence evasion and metastasis. The molecular basis of hTERT regulation is highly complicated and consists of various layers. A deep and full-scale comprehension of the regulatory mechanisms of hTERT is pivotal in understanding the pathogenesis and searching for therapeutic approaches. In this review, we summarize the recent advances regarding the diverse regulatory mechanisms of hTERT, including the transcriptional (promoter mutation, promoter region methylation and histone acetylation), post-transcriptional (mRNA alternative splicing and non-coding RNAs) and post-translational levels (phosphorylation and ubiquitination), which may provide novel perspectives for further translational diagnosis or therapeutic strategies targeting hTERT. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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