Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
| Autor: | Amang André Perfusion, Paul V. Tan, Nkwengoua Ernestine, Nyasse Barthélemy |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Advances in Pharmacological Sciences, Vol 2014 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1687-6334 1687-6342 |
| DOI: | 10.1155/2014/323470 |
| Popis: | Objective. The objective of this study was to find out the possible antiulcer mechanism of action of Eremomastax speciosa. Method. Carbachol- and histamine-induced hypersecretion, associated with the pylorus ligation technique, were used in rats. Gastric mucosal ulceration, mucus production, pH, gastric volume, and acidity were measured. Results. Histamine and carbachol raised gastric acidity to 86.50 and 84.80 mEq/L, respectively, in the control rats, and the extracts (200 mg/kg) reduced gastric acidity to 34.60 and 39.00 mEq/L, respectively. Intraduodenal aqueous extract (400 mg/kg) in histamine- and carbachol-treated rats produced significant (P |
| Databáze: | Directory of Open Access Journals |
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