Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2

Autor:	Shuqi Wu, Xiaochun Tian, Qian Mao, Chang Peng
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Wheezing diseases Histone methylation Azithromycin EZH2 Pulmonary inflammation Medicine Genetics QH426-470
Zdroj:	Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Druh dokumentu:	article
ISSN:	1868-7083
DOI:	10.1186/s13148-023-01430-y
Popis:	Abstract Background Histone methylation modification plays an irreplaceable role in the wheezing diseases. The aim of this study was to explore whether azithromycin (AZM) attenuates post-inflammatory wheezing through inhibiting hypermethylation of histone H3K27me3 mediated by EZH2. Results A randomized controlled trial was conducted on 227 children who underwent fiber-optic bronchoscopy, and bronchoalveolar lavage fluid (BALF) was collected for analyses. The expressions of IL-6, IL-2, NF-κB P65, EZH2 and H3K27me3 in the BALF of wheezing cases were significantly increased when compared with levels in non-wheezing cases (P
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