| Autor: |
Pankaj B. Miniyar, Anand A. Mahajan, Santosh N. Mokale, Mauli U. Shah, Ashish S. Kumar, Ganesh U. Chaturbhuj |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 10, Iss 3, Pp 295-299 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2013.09.005 |
| Popis: |
The present work involves synthesis of novel anti-fungal agents containing triazole scaffold. The newly designed compounds were synthesized on the trails of ketoconazole using the molecular hybridization approach. A series of 10 compounds having (2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl esters (4a–j) were prepared by conventional synthetic approach. The synthesized compounds were subjected for in vitro anti-fungal screening against Aspergillus niger, Aspergillus fumigatus, Candida albicans and Penicillium notatum. Out of 10 newly synthesized compounds, six compounds (4b–f and j) showed remarkable anti-fungal activity (MIC range 6.5–25 μg/ml), whereas compound 4d (MIC 6.5 μg/ml) was more potent than standard drug ketoconazole (MIC 12.5 μg/ml). These triazole hybrids can be considered as potential anti-fungal agents. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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