Signatory metabolomics biomarkers of stress, anxiety, and depression: a proof of concept for precision health among university students: A cross-sectional study
| Autor: | Nur Izzati Umar Zaman, Teh Lay Kek, Rohana Ahmad, Mohd Nur Fakhruzzaman Noorizhab, Mohd Salleh Rofiee, Richard Johari James, Norazmir Md Nor, Mawarni Mohamed, Teoh Sian Hoon, Parmjit Singh Arepar Singh, Roziah Mohd Janor, Sahol Hamid Abu Bakar, Mohd Zaki Salleh |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Precision and Future Medicine, Vol 7, Iss 1, Pp 33-43 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2508-7940 2508-7959 |
| DOI: | 10.23838/pfm.2022.00128 |
| Popis: | Purpose The highly competitive nature of tertiary education and the pressure to perform academically have increased psychological morbidity like emotional distress. Untargeted metabolomics was used to analyze serum samples of university students for biomarkers and perturbated metabolism due to stress, anxiety, and depression (SAD). Methods Depression, Anxiety, Stress Scale 21 (DASS-21) was used to assess the severity of SAD in university students. The metabolite fingerprint of each subject was obtained using liquid chromatography-mass spectrometry quadrupole time-of-flight (LC/MS QTOF). The signature metabolites for each trait were determined by projections to latent structures discriminant analysis (PLS-DA) with variable importance for the projection (VIP) score > 1.0 (P |
| Databáze: | Directory of Open Access Journals |
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