| Autor: |
Mahdi Aghaei, Farhood Alizadegan, Yosra Raziani, Githa Kishore, Massumeh Saadatmand, Suja Ajoy Kumar |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of HerbMed Pharmacology, Vol 12, Iss 4, Pp 592-596 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2345-5004 |
| DOI: |
10.34172/jhp.2023.44897 |
| Popis: |
Introduction: Leishmaniasis caused by Leishmania spp. is observed in most parts of the world. Although, glucantime, a pentavalent antimony compound, and other synthetic drugs are broadly applied for leishmaniasis therapy; however, the use of these synthetic agents has some limitations. Hence, this study was designed to assess the inhibiting effects of 7-hydroxy4′-methoxyisoflavone (7HMI) against promastigote and amastigote stages of Leishmania major in vitro. Methods: The MTT assay was applied to study the antileishmanial activity of 7HMI against promastigotes and its cytotoxicity effects on macrophage cells. The nitric oxide (NO) produced by the treated macrophage cells with 7HMI was also assessed. Results: 7HMI considerably (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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