Blood MALT1 deficiency is common and relates to unfavorable induction therapy response and survival profile in acute myeloid leukemia patients

Autor:	Haili Geng, Yiting Wang, Shaoyuan Wang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Acute myeloid leukemia mucosa-associated lymphoid tissue lymphoma translocation protein 1 risk stratification induction therapy response survival profile Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Hematology, Vol 27, Iss 1, Pp 1176-1183 (2022)
Druh dokumentu:	article
ISSN:	16078454 1607-8454
DOI:	10.1080/16078454.2022.2139909
Popis:	Background Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) regulates T helper/regulatory T cell balance, autoimmunity development, and leukemia pathogenesis. As a result, this study aimed to investigate the clinical role of MALT1 in patients with acute myeloid leukemia (AML).Methods MALT1 expressions were measured in peripheral blood mononuclear cell (PBMC) from 90 newly diagnosed AML patients before and after induction treatment using RT-qPCR. Moreover, MALT1 expressions were also determined in 50 disease controls (DCs) and 50 healthy controls (HCs).Results MALT1 expression was reduced in AML patients compared to HCs and DCs (both adjusted P 10×109/L (P = .037) and poor risk stratification (P = .020) in AML patients. MALT1 expression was elevated during induction treatment not only in total AML patients (P
Databáze:	Directory of Open Access Journals
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