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Background Gastroesophageal reflux disease (GERD) has a high incidence and a heavy disease burden in recent years, but there is a lack of data to understand the burden of GERD in China. This study describes and analyzes the disease burden of GERD in order to better understand the prevalence of GERD in China. Objective To analyze the disease burden and prevalence trend of GERD in China from 1990 to 2019, and to provide a reference for the prevention and treatment of GERD in China. Methods Crude and standardized incidence, prevalence, and DALY rates of GERD in China from 1990 to 2019 were obtained from the Global Burden of Disease Database 2019 (GBD 2019) ; the rate of change was calculated, and Joinpoint regression model was used to analyze the standardized incidence, prevalence, and DALY rates of GERD, and the annual percentage change (APC) was calculated. Results In 2019, the crude rate and standardized rate of GERD incidence in China were 2 299.80 per 100 000 and 1 841.66 per 100 000, respectively. Compared with 1 761.59 per 100 000 and 1 849.31 per 100 000 in 1990, the crude rate increased by 30.55%, and the standardized rate decreased by 0.41%. In 2019, the crude rate and standardized rate of GERD prevalence in China were 5 739.55 per 100 000 and 4 509.32 per 100 000, respectively. Compared with 4 252.72 per 100 000 and 4 532.19 per 100 000 in 1990, the crude rate increased by 34.96%, and the standardized rate decreased by 0.51%. In 2019, the crude rate and standardized rate of GERD DALY rate in China were 44.37 per 100 000 and 34.94 per 100 000, respectively. Compared with 33.10 per 100 000 and 35.04 per 100 000 in 1990, the crude rate increased by 34.05%, and the standardized rate decreased by 0.29%. The standardized incidence, prevalence, and DALY rates were lower than crude rates after 1996. The standardized incidence, prevalence, and DALY rates of Chinese women were higher than those of men from 1990 to 2019. The results of Joinpoint regression analysis showed that the standardized incidence of GERD in China showed a downward trend from 1990 to 1994 (APC=-1.0%), a downward trend from 2005 to 2010 (APC=-1.4%), and an upward trend from 2014 to 2017 (APC=3.2%). The standardized prevalence of GERD in China showed a downward trend from 1990 to 1994 (APC=-1.2%), a downward trend from 2005 to 2009 (APC=-1.7%), and an upward trend from 2014 to 2017 (APC=3.7%). The standardized DALY rates of GERD in China showed a downward trend from 1990 to 1994 (APC=-1.1%), a downward trend from 2005 to 2009 (APC=-1.7%), and an upward trend from 2014 to 2017 (APC=3.6%). In 2019, the standardized incidence, prevalence, and DALY rates of GERD in China continued to increase with age, peaking at the age of 70 to 84 years. The number of new cases and cases of GERD in 2019 were respectively about 32.711 3 million and 81.636 5 million, and the populations were mainly concentrated in the age group of 45 to 59 years and 30 to 34 years. Conclusion From 1990 to 2019, the disease burden of GERD in China showed an upward trend in terms of crude rate and a slight decline in terms of standardized rate, indicating that aging had a great impact on the incidence, prevalence and DALY rate of GERD in China. In addition, it is important to pay attention to the middle-aged and young population, who account for a larger proportion of the population already suffering from GERD and may be closely related to overweight or obesity, alcohol consumption and dietary habits, etc. |
