Cancer treatment regimens and their impact on the patient-reported outcome measures health-related quality of life and perceived cognitive function

Autor: Niklas Paul Grusdat, Alexander Stäuber, Marion Tolkmitt, Jens Schnabel, Birgit Schubotz, Peter Richard Wright, Marc Heydenreich, Dirk-Henrik Zermann, Henry Schulz
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Patient-Reported Outcomes, Vol 6, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2509-8020
DOI: 10.1186/s41687-022-00422-5
Popis: Abstract Background and purpose Breast cancer can be a significant challenge for those affected. Knowledge of physical function, social-emotional challenges, and perceived cognitive function based on the cancer treatment regimens may help to inform adequate support. Methods For this prospective observational pilot study, we collected data of seventy-nine women (mean age 54.6 ± 9.5 years) before (T0) and after (T1) initial breast cancer treatment. Functional Assessment of Cancer Therapy-Breast (FACT-B) and Functional Assessment of Cancer Therapy–Cognitive-Function (FACT-Cog) were used to collect data of four treatment subgroups: SCR = Surgery + Chemotherapy + Radiation Therapy; SC = Surgery + Chemotherapy; SR = Surgery + Radiation Therapy; S = Surgery. A mixed ANOVA and posthoc analysis (Tukey, Games-Howell) were used to detect interactions (group by time) and the main effect. A repeated-measures ANOVA displayed individual group differences (time). Results Significant interaction showed more deterioration was experienced with SC and SCR than SR and S for FACT-B (p
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