Pretreatment quality of life as a predictor of survival for patients with nasopharyngeal carcinoma treated with IMRT

Autor: Shan-Shan Guo, Wen Hu, Qiu-Yan Chen, Jian-Mei Li, Shi-Heng Zhu, Yan He, Jia-Wen Li, Le Xia, Lu Ji, Cui-Ying Lin, Li-Ting Liu, Lin-Quan Tang, Ling Guo, Hao-Yuan Mo, Chong Zhao, Xiang Guo, Ka-Jia Cao, Chao-Nan Qian, Mu-Sheng Zeng, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma, Yu-Ying Fan, Hai-Qiang Mai
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Druh dokumentu: article
ISSN: 1471-2407
DOI: 10.1186/s12885-018-4003-8
Popis: Abstract Background To evaluate the prognostic significance of pretreatment quality of life for patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy. Methods We performed a prospective, longitudinal study on 554 newly diagnosed patients with NPC from April 2011 to January 2015. A total of 501 consecutive NPC patients were included. Patients were asked to complete the EORTC QLQ-C30 (version 3.0) and QLQ-H&N35 questionnaires before treatment. Results Global health status among QLQ-C30 correlates with EBV DNA(P = 0.019). In addition, pretreatment appetite loss was significantly correlated with EBV DNA(P = 0.02). Pretreatment teeth, opening mouth, feeding tube was significantly correlated with EBV DNA, with P value of 0.003,
Databáze: Directory of Open Access Journals
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