Age-associated decrease in de novo donor-specific antibodies in renal transplant recipients reflects changing humoral immunity

Autor:	Seraina von Moos, Gesa Schalk, Thomas F. Mueller, Guido Laube
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	De novo donor specific antibodies Aging Older kidney transplant recipients Pediatric kidney transplant recipients Immunosenescence Immunologic diseases. Allergy RC581-607 Geriatrics RC952-954.6
Zdroj:	Immunity & Ageing, Vol 16, Iss 1, Pp 1-8 (2019)
Druh dokumentu:	article
ISSN:	1742-4933
DOI:	10.1186/s12979-019-0149-8
Popis:	Abstract Background Older age at organ transplantation is associated with increased risk of infection and malignancy but reduced risk of cellular rejection. De novo donor-specific anti-HLA antibodies (dnDSA), are key biomarkers associated with reduced long-term allograft survival, yet there is a lack of data focusing on age-associated changes. Methods Development of dnDSA was restrospectively analyzed in all subjects who received a kidney transplant at the University Hospital Zurich between 01/2006 and 02/2015. Follow up continued until 03/2016. The incidence of dnDSA in different age categories was compared with special focus on the extremes of age: children
Databáze:	Directory of Open Access Journals
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