| Autor: |
Audrie Lin, Andrew N. Mertens, Md. Ziaur Rahman, Sophia T. Tan, Dora Il’yasova, Ivan Spasojevic, Shahjahan Ali, Christine P. Stewart, Lia C. H. Fernald, Lisa Kim, Liying Yan, Ann Meyer, Md. Rabiul Karim, Sunny Shahriar, Gabrielle Shuman, Benjamin F. Arnold, Alan E. Hubbard, Syeda L. Famida, Salma Akther, Md. Saheen Hossen, Palash Mutsuddi, Abul K. Shoab, Idan Shalev, Mahbubur Rahman, Leanne Unicomb, Christopher D. Heaney, Patricia Kariger, John M. Colford, Stephen P. Luby, Douglas A. Granger |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-024-47896-z |
| Popis: |
Abstract A regulated stress response is essential for healthy child growth and development trajectories. We conducted a cluster-randomized trial in rural Bangladesh (funded by the Bill & Melinda Gates Foundation, ClinicalTrials.gov NCT01590095) to assess the effects of an integrated nutritional, water, sanitation, and handwashing intervention on child health. We previously reported on the primary outcomes of the trial, linear growth and caregiver-reported diarrhea. Here, we assessed additional prespecified outcomes: physiological stress response, oxidative stress, and DNA methylation (N = 759, ages 1–2 years). Eight neighboring pregnant women were grouped into a study cluster. Eight geographically adjacent clusters were block-randomized into the control or the combined nutrition, water, sanitation, and handwashing (N + WSH) intervention group (receiving nutritional counseling and lipid-based nutrient supplements, chlorinated drinking water, upgraded sanitation, and handwashing with soap). Participants and data collectors were not masked, but analyses were masked. There were 358 children (68 clusters) in the control group and 401 children (63 clusters) in the intervention group. We measured four F2-isoprostanes isomers (iPF(2α)-III; 2,3-dinor-iPF(2α)-III; iPF(2α)-VI; 8,12-iso-iPF(2α)-VI), salivary alpha-amylase and cortisol, and methylation of the glucocorticoid receptor (NR3C1) exon 1F promoter including the NGFI-A binding site. Compared with control, the N + WSH group had lower concentrations of F2-isoprostanes isomers (differences ranging from −0.16 to −0.19 log ng/mg of creatinine, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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