Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions

Autor:	S. D. Dowall, V. A. Graham, K. Corbin-Lickfett, C. Empig, K. Schlunegger, C. B. Bruce, L. Easterbrook, R. Hewson
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Immunologic diseases. Allergy RC581-607
Zdroj:	Journal of Immunology Research, Vol 2015 (2015)
Druh dokumentu:	article
ISSN:	2314-8861 2314-7156
DOI:	10.1155/2015/347903
Popis:	Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/91c5ea9b8953419998449a915f3d3920 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF