| Autor: |
Saqib Ali, John Igoli, Carol Clements, Dima Semaan, Muhammad Alamzeb, Mamoon Ur Rashid, Syed Qaisar Shah, Valerie A. Ferro, Alexander I. Gray, Muhammad Rafiullah Khan |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Bangladesh Journal of Pharmacology, Vol 8, Iss 3 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1991-0088 |
| Popis: |
Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and gluta-mic acid were isolated from the active fractions of these species for the first time. The antidiabetic activity was determined against Protein Tyrosine Phosphatase 1B (PTP 1B), a negative insulin regulator while the antimicrobial activity was performed against four bacterial strains: Mycobacterium marinum ATCC BAA535, sporadic Methicillin Resistant Staphylococcus aureus (SMRSA), endemic Methicillin Resistant Staphylococcus aureus (EMRSA) and Escherichia coli ATCC.8739 at different concentrations. Amongst the isolated compounds 8-oxo-berberine was found to be the most active antidiabetic (29 % of the positive control) while jatrorrhizine was the most active and selective antimicrobial against SMRSA and EMRSA (-1.2% of the DMSO (D) control). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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