| Autor: |
Chunjin Zhang, Jing Li, Yipu Sai, Haitao Su, Youxu Jiang, Lihua Zhang, Liguo Jian, Hui Zhang, Guangli Guo, En Li, Xiaowei Li, Liqiang Sun |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Stem Cell Research, Vol 81, Iss , Pp 103586- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2024.103586 |
| Popis: |
Dilated Cardiomyopathy (DCM), a prevalent form of cardiomyopathy, is characterized by ventricular dilation and systolic dysfunction. Its etiology is intricate, encompassing multiple genetic and environmental elements. The LMOD2 (Leiomodin 2) gene has been demonstrated to be closely associated with the pathogenesis of DCM. In this study, a pure cell line was generated by knocking out the LMOD2 gene, and a DCM cell model was established through induced differentiation, thus providing a powerful experimental approach for further understanding the pathogenesis of DCM. It also provides a potential research orientation for the early diagnosis and individualized treatment of DCM. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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