The impact of high polymerization inulin on body weight reduction in high-fat diet-induced obese mice: correlation with cecal Akkermansia

Autor: Liping Gan, Yifeng Zhao, Zongbao Zhang, Chenkai Zhao, Jiake Li, Qingyu Jia, Yusu Shi, Peng Wang, Linna Guo, Hanzhen Qiao, Yaoming Cui, Jinrong Wang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Microbiology, Vol 15 (2024)
Druh dokumentu: article
ISSN: 1664-302X
DOI: 10.3389/fmicb.2024.1428308
Popis: Obesity presents a significant public health challenge, demanding effective dietary interventions. This study employed a high-fat diet-induced obesity mouse model to explore the impacts of inulin with different polymerization degrees on obesity management. Our analysis reveals that high-degree polymerization inulin (HDI) exhibited a significantly higher oil binding capacity and smaller particle size compared to low-degree polymerization inulin (LDI) (p 0.05, respectively). These findings underscore the importance of the structural properties of inulin in its potential to combat obesity and highlight the strategic use of inulin with varying polymerization degrees as a promising dietary approach for obesity management, particularly in its influence on gut microbiota composition and hepatic lipid metabolism regulation.
Databáze: Directory of Open Access Journals