Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease

Autor:	Yael Kusne, Michael Christiansen, Christopher Conley, Juan Gea-Banacloche, Ayan Sen
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Zdroj:	Case Reports in Critical Care, Vol 2021 (2021)
Druh dokumentu:	article
ISSN:	2090-6420 2090-6439
DOI:	10.1155/2021/6612710
Popis:	Background. Hemophagocytic lymphohistiocytosis (HLH) was originally described in pediatric patients presenting with fever, hepatosplenomegaly, and blood cell abnormalities. Later, HLH was recognized to occur in adults, often associated with hematologic malignancies or serious infections. Conclusion. Patients presenting with HLH are critically ill, and rapid diagnosis is key. In adults, the search for the trigger must begin promptly as time to diagnosis effects survival. The underlying trigger in our patients was Histoplasma capsulatum infection, which is rare in the southwestern United States. Prompt diagnosis led to recovery in one patient, while the other did not survive.
Databáze:	Directory of Open Access Journals
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