Mechanically interlocked functionalization of monoclonal antibodies

Autor: Krzysztof P. Bzymek, James W. Puckett, Cindy Zer, Jun Xie, Yuelong Ma, Jeremy D. King, Leah H. Goodstein, Kendra N. Avery, David Colcher, Gagandeep Singh, David A. Horne, John C. Williams
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-03976-5
Popis: Meditope-Fab is a peptide-antibody complex potentially useful for drug delivery and diagnostic, but a short half-life prevents its use in vivo. Here the authors engineer the complex to improve its stability, create functionalized antibodies by click chemistry and use them for in vivo tumor imaging.
Databáze: Directory of Open Access Journals