| Autor: |
C. Navas-Enamorado, X. Capo, A.M. Galmes-Panades, A. Ortega-Moral, A. Sánchez-Polo, L. Masmiquel, M. Torrens-Mas, P. Navas, M. Gonzalez-Freire |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Experimental Gerontology, Vol 194, Iss , Pp 112488- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1873-6815 |
| DOI: |
10.1016/j.exger.2024.112488 |
| Popis: |
Aging is an inevitable and gradual decline in several biological functions. Mitochondrial dysfunction is one of the most important hallmarks of aging. In this context, alterations in metabolites associated with mitochondrial dysfunction may serve as a significant biomarker. This study aimed to investigate the existence of a relationship between the key metabolites involved in bioenergetics metabolism and aging. 53 volunteers ranged 20–85 years participated in the study. We tested the association between different tricarboxylic acid (TCA) cycle metabolites, fatty acid metabolism, and amino acid metabolism with age, sex, body composition, and proxy markers of aging such as walking speed, grip strength and chair test. We found that lactic acid negatively correlated with age while several fatty acid metabolites, such as azelaic, sebacic, and linoleic acids, showed positive correlations with age (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect