| Autor: |
Rakhmad Hidayat, Al Rasyid, Salim Harris, Alida R. Harahap, Herqutanto, Melva Louisa, Erlin Listiyaningsih, Aldy Safruddin Rambe, Tonny Loho |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 59, Iss 1, Pp 1-7 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1687-8329 |
| DOI: |
10.1186/s41983-023-00712-9 |
| Popis: |
Abstract Introduction Clopidogrel is recommended as an alternative to Acetyl Salicylic Acid (ASA), the first-line drug for secondary stroke prevention. Clopidogrel resistance in Indonesia is reportedly 15.8%. The Stent Thrombosis in Belgium (STIB) is a scoring system proposed to assess clopidogrel resistance which has not been tested for the reliability in Indonesian population. Objectives The objective of the study is to test the reliability of the STIB scoring and modified-STIB scoring system in Indonesian population. Methods This study was conducted cross-sectionally in Dr. Cipto Mangunkusumo Hospital and Universitas Indonesia Hospital from January 2020 to December 2021. Laboratory examinations of human CYP450 concentration in blood plasma from 112 subjects were carried out using the ELISA method. The clopidogrel resistance test was carried out using the VerifyNow method. Results Out of 112 ischemic stroke patients in this study, 14.3% of them did not respond to clopidogrel. Cross-tabulation between the STIB score and clopidogrel resistance showed significant results (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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