Transplantation of neuron‐inducing grafts embedding positively charged gold nanoparticles for the treatment of spinal cord injury

Autor:	Wan‐Kyu Ko, Seong Jun Kim, Gong Ho Han, Daye Lee, Dabin Jeong, Sang Jin Lee, In‐Bo Han, Je Beom Hong, Seung Hun Sheen, Seil Sohn
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	astrocyte gold nanoparticle neural stem cell neuron spinal cord injury Chemical engineering TP155-156 Biotechnology TP248.13-248.65 Therapeutics. Pharmacology RM1-950
Zdroj:	Bioengineering & Translational Medicine, Vol 7, Iss 3, Pp n/a-n/a (2022)
Druh dokumentu:	article
ISSN:	2380-6761
DOI:	10.1002/btm2.10326
Popis:	Abstract In this study, we aimed to investigate the recovery after traumatic spinal cord injury (SCI) by inducing cellular differentiation of transplanted neural stem cells (NSCs) into neurons. We dissociated NSCs from the spinal cords of Fisher 344 rat embryos. An injectable gel crosslinked with glycol chitosan and oxidized hyaluronate was used as a vehicle for NSC transplantation. The gel graft containing the NSC and positively charged gold nanoparticles (pGNP) was implanted into spinal cord lesions in Sprague–Dawley rats (NSC‐pGNP gel group). Cellular differentiation of grafted NSCs into neurons (stained with β‐tubulin III [also called Tuj1]) was significantly increased in the NSC‐pGNP gel group (***p
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