Glutathione transferases polymorphism in human brain gliomas and their value for prognosis of chemotherapy efficiency
| Autor: | I. G. Vasilyeva, V. D. Rozumenko, A. Ya. Glavatsky, N. G. Chopick, N. P. Olexenko, E. S. Galanta, O. I. Tsyubko, N. D. Snitsar |
|---|---|
| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Ukrainian Neurosurgical Journal, Iss 4, Pp 36-40 (2009) |
| Druh dokumentu: | article |
| ISSN: | 2663-9092 2663-9084 |
| DOI: | 10.25305/unj.108009 |
| Popis: | Glutathione S-transferases common activity, genotypes of glutathione transferases mu and theta and also levels of glutathione transferase pi expression in human brain gliomas (80 samples: 10 low-grade diffuse astrocytomas, 19 anaplastic astrocytomas, 37 glioblastomas, 9 oligodendroastrocytomas, 5 oligodendrogliomas) of different malignancy grade were investigated. The results of conducted researches testified that functional polymorphism of GSTP1 glutathione S-transferases activity correlated with gliomas malignancy grade. Structural polymorphism of GSTM1 and GSTT1 did not depend on the malignancy grade. However, it was set that GSTМ1“0”-genotype presence was more frequent in astrocytomas. Thus, for effective chemotherapy it is necessary to take into account individual features of glutathione transferases dependent chemoresistance. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|