Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient

Autor:	Erica A. Siebrasse, Nang L. Nguyen, Melisa J. Willby, Dean D. Erdman, Marilyn Menegus, David Wang
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	transplant WU polyomavirus immunosuppression epithelial cells tropism viruses Medicine Infectious and parasitic diseases RC109-216
Zdroj:	Emerging Infectious Diseases, Vol 22, Iss 1, Pp 24-31 (2016)
Druh dokumentu:	article
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2201.151384
Popis:	WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient’s lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/91369a1923a441ae85a08bef8c4002e3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.