Impact of baseline body composition on prognostic outcomes in urological malignancies treated with immunotherapy: a pooled analysis of 10 retrospective studies

Autor:	Wangbin Ma, Qiao Shi, Lilong Zhang, Zhendong Qiu, Tianrui Kuang, Kailiang Zhao, Weixing Wang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Immune checkpoint inhibitors Body composition Skeletal muscle index Psoas muscle index Sarcopenia Urological malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-024-12579-x
Popis:	Abstract Objective Numerous epidemiological investigations have explored the impact of body composition on the effectiveness of immune checkpoint inhibitors (ICIs) in urological malignancies (UM) patients, yielding conflicting findings. As a result, our study aims to elucidate the influence of baseline body composition on the long-term prognosis of UM patients treated with ICIs. Methods We employed a rigorous systematic search across various databases, including PubMed, Embase, the Cochrane Library, and Google Scholar, to identify studies meeting our inclusion criteria. Our primary endpoints of interest encompassed overall survival (OS) and progression-free survival (PFS). Results This analysis included a total of 10 articles with a combined patient cohort of 707 individuals. Our findings revealed a noteworthy association between several body composition parameters and unfavorable OS outcomes, including low psoas muscle index (PMI; HR: 3.88, p
Databáze:	Directory of Open Access Journals
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