Metabolomics and Incidence of Atrial Fibrillation in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study.
| Autor: | Alvaro Alonso, Bing Yu, Waqas T Qureshi, Morgan E Grams, Elizabeth Selvin, Elsayed Z Soliman, Laura R Loehr, Lin Y Chen, Sunil K Agarwal, Danny Alexander, Eric Boerwinkle |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | PLoS ONE, Vol 10, Iss 11, p e0142610 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1932-6203 42684625 |
| DOI: | 10.1371/journal.pone.0142610 |
| Popis: | Atrial fibrillation (AF) is a common arrhythmia. Application of metabolomic approaches, which may identify novel pathways and biomarkers of disease risk, to a longitudinal epidemiologic study of AF has been limited.We determined the prospective association of 118 serum metabolites identified through untargeted metabolomics profiling with the incidence of newly-diagnosed AF in 1919 African-American men and women from the Atherosclerosis Risk in Communities study without AF at baseline (1987-1989). Incident AF cases through 2011 were ascertained from study electrocardiograms, hospital discharge codes, and death certificates.During a median follow-up of 22 years, we identified 183 incident AF cases. In Cox proportional hazards models adjusted for age, sex, smoking, body mass index, systolic blood pressure, use of antihypertensive medication, diabetes, prevalent heart failure, prevalent coronary heart disease, and kidney function, two conjugated bile acids (glycolithocholate sulfate and glycocholenate sulfate) were significantly associated with AF risk after correcting for multiple comparisons (p |
| Databáze: | Directory of Open Access Journals |
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