Ultrastructural changes in murine liver following HSV infection and stroke
| Autor: | Motorna Natalia, Rybalko Svetlana, Kvitnitskaya-Ryzhova Tatyana, Starosyla Daria, Strokina Iryna, Kaminsky Rostyslav, Savosko Sergey, Sokurenko Liudmyla, Chaikovsky Yuri |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Current Issues in Pharmacy and Medical Sciences, Vol 31, Iss 1, Pp 10-12 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2084-980X 2300-6676 |
| DOI: | 10.1515/cipms-2018-0002 |
| Popis: | The study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied, little is known about the damage to other organs which are not a source of latent HSV-I infection, the liver in particular. The current study is aimed at determining the ultrastructural changes in murine liver following HSV infection and stroke. Liver samples obtained from four groups of animals were studied: 1) intact mice; 2) mice with stroke; 3) mice infected with HSV-I; 4) mice aflicted with HSV-I and subsequently simulated stroke. The study showed the reproduction of the virus in hepatic endotheliocytes, although no virions were detected in the hepatocytes. Therefore, the described changes were considered the consequences of the infectious process. Pathological changes of hepatocytes consisted of deformation and fragmentation of the nuclei, as well as accumulation of osmiophilic granules, lysosomes and lamellary bodies. Latent HSV-I infection may reactivate in liver after the stroke, potentially causing the complications of the underlying disease. |
| Databáze: | Directory of Open Access Journals |
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