Real-world effectiveness of the inactivated COVID-19 vaccines against variant of concerns: meta-analysis
| Autor: | Muhammad Usman Sarwar, Fathimathuz Zehra Waasia, Akram Ahmed Aloqbi, Maher Alandiyjany, Reem Mohammed Alqahtani, Lubna Abdulrahman Hafiz, Ghalia Shamlan, Mohammed Albreiki |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Infection and Public Health, Vol 17, Iss 2, Pp 245-253 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1876-0341 91155649 |
| DOI: | 10.1016/j.jiph.2023.12.005 |
| Popis: | Background: COVID-19 has killed over 6 million people worldwide, making it the worst global health disaster since the 1918 influenza pandemic. Experts have worked to establish the source, track and analyse the disease, and produce treatment and preventative guidelines. Inactivated vaccines have little evidence of efficacy compared to mRNA and adenoviral vector vaccines; however, three doses of both mRNA and inactivated vaccines appear to provide significant and lasting protection against severe disease and mortality. This study examines inactivated vaccine effectiveness data by disease status, age, gender, primary immunisation, booster doses, and SARS-CoV2 virus types. Methods: We conducted a quantitative epidemiological meta-analysis study to assess the vaccine effectiveness of inactivated COVID-19 vaccines. Data extraction was performed on the selected studies, and data analysis was conducted using a random-effects model to determine consolidated assessments of vaccine effectiveness. Subgroup analyses were conducted for gender, age, disease level, and vaccine status, and sensitivity analyses were conducted to assess the robustness of the results. Results: The overall effect size of inactivated COVID-19 vaccinations was statistically significant (p-value |
| Databáze: | Directory of Open Access Journals |
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