CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages

Autor: Milton Pereira, Panagiotis Tourlomousis, John Wright, Tom P. Monie, Clare E. Bryant
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms12874
Popis: IL-1β is important for control of bacterial infections, but when deregulated can lead to excessive inflammation. The authors show that the adaptor protein CARD9 suppresses levels of IL-1β and is downregulated during S. Typhimuriuminfection, thus facilitating an inflammatory response
Databáze: Directory of Open Access Journals