Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS2@Cu2O-Au Nanocomposites

Autor:	Yan Yu, Haiyu Xie, Tao Zhou, Haonan Zhang, Chenze Lu, Ran Tao, Zhaozhao Tang, Jingting Luo
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Love-mode surface acoustic wave (L-SAW) immunosensor nanocomposite prostate-specific antigen (PSA) real time ultrasensitive Chemical technology TP1-1185
Zdroj:	Sensors, Vol 24, Iss 23, p 7636 (2024)
Druh dokumentu:	article
ISSN:	1424-8220
DOI:	10.3390/s24237636
Popis:	Prostate-specific antigen (PSA) is a well-established tumour marker for prostatic carcinoma. In this study, we present a novel, real-time, and ultrasensitive Love-mode surface acoustic wave (L-SAW) immunosensor for PSA detection enhanced by MoS2@Cu2O-Au nanocomposite conjugation. The MoS2@Cu2O-Au nanocomposites were analyzed by SEM, XRD, and EDS. The experiments show a significant improvement in sensitivity and detection limit compared with the previous detection methods utilizing nanogold alone to detect PSA biomolecules. The experimental results show a good linear relationship when the range of PSA concentrations between 200 pg/mL and 5 ng/mL was tested. The experimental results also show good specificity against alpha 1 fetoprotein and L-tryptophan disruptors.
Databáze:	Directory of Open Access Journals
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