Autoimmune Hepatitis after AstraZeneca Coronavirus Disease 2019 (COVID-19) vaccine: need for epidemiological study
| Autor: | Sofia Bizarro Ponte, Inês Clara, Inês Furtado |
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| Jazyk: | English<br />Spanish; Castilian<br />Galician<br />Portuguese |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Galicia Clínica, Vol 83, Iss 3, Pp 38-39 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0304-4866 1989-3922 |
| DOI: | 10.22546/66/2791 |
| Popis: | This case-report and brief review of literature were written concerning autoimmune hepatitis potentially triggered by virus vaccines. Soon after the Astrazeneca COVID-19 vaccine, a 70-year-old women presented with jaundice and nausea, with significant hepatic injury (aspartate aminotransferase (AST) 746 U/L; hyperbilirubinemia 9,30 mg/dL (conjugated bilirubin 7,14 mg/dL), elevated immunoglobulin (Ig) G and antinuclear, anti-smooth muscle and anti-actin F antibodies were detected. Considering autoimmune hepatitis (AIH) as a possible cause, a liver biopsy was performed and compatible with AIH. Prednisolone therapy was initiated, with optimal response. This report suggests that immunization against COVID-19 might precipitate or induce AIH. Further data regarding confirmed cases of AIH are mandatory in order to establish a causal link. Therefore, long-term pharmacovigilance surveillance of large cohorts of patients is needed. |
| Databáze: | Directory of Open Access Journals |
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