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Aim:The role of systemic inflammation in lung cancer patients is known. Diagnosis and treatment of psychiatric disorders, especially depression, can increase patients’ adherence to treatment and life quality. We aimed to investigate the relationship between inflammatory markers and depression in patients with de novo metastatic lung cancer.Materials and Methods:Sixty-six patients newly diagnosed with de novo metastatic lung cancer between January and December 2021 were included in our study. Baseline characteristics, laboratory findings, and the Beck Depression Inventory (BDI) of patients were evaluated at the pre-chemotherapy visit.Results:Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and systemic inflammation response index (SII) were significantly higher in the group with depression. NLR, PLR, C-reactive protein to lymphocyte ratio and SII values showed a positive correlation with BDI scores, indicating depression. It was determined that the values of 3.63 for NLR, 173 for PLR and 1208 for SII could be used as cut-off values to detect depression.Conclusion:Although the biopsychosocial approach is important in terms of disease prognosis during oncological evaluation, cancer remains the main life-threatening disease, making it difficult for clinicians to screen for depression unless the patient has an additional request. Predicting the possible risk of depression via common laboratory values measured at the time of diagnosis will significantly contribute to the treatment process of the patients. |
