Autor: |
Yunhao Wang, Genjiang Zheng, Xiaoxing Xie, Wei Yu, Jianxi Wang, Fazhi Zang, Chen Yang, Qiangqiang Xiao, Rongcheng Zhang, Leixin Wei, Xiaodong Wu, Lei Liang, Peng Cao, Chen Xu, Jing Li, Bo Hu, Tao Zhang, Jinglei Wu, Huajiang Chen |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-18 (2023) |
Druh dokumentu: |
article |
ISSN: |
1477-3155 |
DOI: |
10.1186/s12951-023-01823-4 |
Popis: |
Abstract Intervertebral disc degeneration (IDD) has been identified as one of the predominant factors leading to persistent low back pain and disability in middle-aged and elderly people. Dysregulation of Prostaglandin E2 (PGE2) can cause IDD, while low-dose celecoxib can maintain PGE2 at the physiological level and activate the skeletal interoception. Here, as nano fibers have been extensively used in the treatment of IDD, novel polycaprolactone (PCL) nano fibers loaded with low-dose celecoxib were fabricated for IDD treatment. In vitro studies demonstrated that the nano fibers had the ability of releasing low-dose celecoxib slowly and sustainably and maintain PGE2. Meanwhile, in a puncture-induced rabbit IDD model, the nano fibers reversed IDD. Furthermore, low-dose celecoxib released from the nano fibers was firstly proved to promote CHSY3 expression. In a lumbar spine instability-induced mouse IDD model, low-dose celecoxib inhibited IDD in CHSY3wt mice rather than CHSY3−/− mice. This model indicated that CHSY3 was indispensable for low-dose celecoxib to alleviate IDD. In conclusion, this study developed a novel low-dose celecoxib-loaded PCL nano fibers to reverse IDD by maintaining PGE2 at the physiological level and promoting CHSY3 expression. |
Databáze: |
Directory of Open Access Journals |
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