PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

Autor: Giulia Mana, Fabiana Clapero, Emiliano Panieri, Valentina Panero, Ralph T. Böttcher, Hui-Yuan Tseng, Federico Saltarin, Elena Astanina, Katarzyna I. Wolanska, Mark R. Morgan, Martin J. Humphries, Massimo M. Santoro, Guido Serini, Donatella Valdembri
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-20 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms13546
Popis: During vascular development, fibronectin (FN) is polymerized at the basolateral side of endothelial cells. Here Mana et al. propose a model where PPFIA1 drives recycling of the FN receptor, a5β1 integrin, to the cell surface and enables polar secretion and fibrillogenesis of newly synthesized FN.
Databáze: Directory of Open Access Journals